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Research paper

Corticosteroids as treatment of epileptic syndromes with continuous spike-waves during slow-wave sleep

Retrospective 44-child cohort. Hydrocortisone 5 mg/kg/day, ~21-month slow taper. Long-lasting response in ~45%. Higher baseline IQ/DQ and shorter CSWS duration before treatment significantly associated with positive steroid response.

Indexed context

Buzatu M, et al.

cswssteroidstaper-strategypediatric-epilepsy

Markdown path

content/research/papers/2009-buzatu-csws-corticosteroids.md

Findings

Retrospective 44-child cohort. Hydrocortisone 5 mg/kg/day, ~21-month slow taper. Long-lasting response in ~45%. Higher baseline IQ/DQ and shorter CSWS duration before treatment significantly associated with positive steroid response.

Why it may matter for Levi

Direct support for a long oral taper strategy in Levi rather than short pulse alone. The IQ-and-duration predictor has mixed implications for Levi (deep regression but dramatic acute response); the long-taper protocol is the single most concrete taper-strategy reference.

Paper text

Corticosteroids as treatment of epileptic syndromes with continuous spike-waves during slow-wave sleep

Buzatu M, et al. — Epilepsia (2009). https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1528-1167.2009.02224.x

Findings summary

Retrospective 44-child cohort. Hydrocortisone 5 mg/kg/day, ~21-month slow taper. Long-lasting response in ~45%. Higher baseline IQ/DQ and shorter CSWS duration before treatment significantly associated with positive steroid response.

Relevance to Levi

Direct support for a long oral taper strategy in Levi rather than short pulse alone. The IQ-and-duration predictor has mixed implications for Levi (deep regression but dramatic acute response); the long-taper protocol is the single most concrete taper-strategy reference.

Provenance

  • Ingested 2026-04-16 as part of the batch literature pass supporting the Root Cause Theories, diagnostics, and treatments workspaces.
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