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Research paper

Differential diagnosis and comparison of diagnostic algorithms in children and adolescents with autoimmune encephalitis in Spain

Prospective cohort comparing Graus and Cellucci algorithms. Mimics common; false-positive serum antibodies common. Specificity of Graus 'possible AE' before infectious testing as low as 8%. Specificity for 'probable seronegative AE' rose to 99% when mimics excluded.

Indexed context

Armangué T, et al.

seronegative-aemimicspediatric-aediagnostic-algorithm

Markdown path

content/research/papers/2024-armangue-pediatric-ae-spain.md

Findings

Prospective cohort comparing Graus and Cellucci algorithms. Mimics common; false-positive serum antibodies common. Specificity of Graus 'possible AE' before infectious testing as low as 8%. Specificity for 'probable seronegative AE' rose to 99% when mimics excluded.

Why it may matter for Levi

Key evidence that a clean seronegative-AE diagnosis in Levi requires ruling out mimics (metabolic, genetic, structural, post-infectious) rather than inferring AE from ambiguous serum cytokines alone.

Paper text

Differential diagnosis and comparison of diagnostic algorithms in children and adolescents with autoimmune encephalitis in Spain

Armangué T, et al. — Lancet Neurology (2024). https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(24)00443-5/abstract

Findings summary

Prospective cohort comparing Graus and Cellucci algorithms. Mimics common; false-positive serum antibodies common. Specificity of Graus 'possible AE' before infectious testing as low as 8%. Specificity for 'probable seronegative AE' rose to 99% when mimics excluded.

Relevance to Levi

Key evidence that a clean seronegative-AE diagnosis in Levi requires ruling out mimics (metabolic, genetic, structural, post-infectious) rather than inferring AE from ambiguous serum cytokines alone.

Provenance

  • Ingested 2026-04-16 as part of the batch literature pass supporting the Root Cause Theories, diagnostics, and treatments workspaces.
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