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Research paper

Seronegative autoimmune encephalitis in children — what's in a name?

Editorial/review emphasizing that the AE label is often applied loosely in pediatrics and that alternative diagnoses are common. Argues for rigorous application of pediatric AE criteria and mimic exclusion.

Indexed context

Titulaer MJ

seronegative-aepediatric-aediagnostic-rigor

Markdown path

content/research/papers/2024-titulaer-seronegative-pediatric-ae.md

Findings

Editorial/review emphasizing that the AE label is often applied loosely in pediatrics and that alternative diagnoses are common. Argues for rigorous application of pediatric AE criteria and mimic exclusion.

Why it may matter for Levi

Directly cautions against calling a case seronegative AE without formal criteria fulfillment — relevant to Levi because the serum Th1/Th17 cytokine pattern alone does not satisfy Cellucci criteria for probable antibody-negative AE.

Paper text

Seronegative autoimmune encephalitis in children — what's in a name?

Titulaer MJ — Developmental Medicine & Child Neurology (2024). https://onlinelibrary.wiley.com/doi/10.1111/dmcn.15911

Findings summary

Editorial/review emphasizing that the AE label is often applied loosely in pediatrics and that alternative diagnoses are common. Argues for rigorous application of pediatric AE criteria and mimic exclusion.

Relevance to Levi

Directly cautions against calling a case seronegative AE without formal criteria fulfillment — relevant to Levi because the serum Th1/Th17 cytokine pattern alone does not satisfy Cellucci criteria for probable antibody-negative AE.

Provenance

  • Ingested 2026-04-16 as part of the batch literature pass supporting the Root Cause Theories, diagnostics, and treatments workspaces.
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  • Companion memo: content/research/notes/2026-04-16-literature-pass.md