Back to research

Research paper

Increased expression of proinflammatory cytokines in the cerebrospinal fluid of patients with a history of electrical status epilepticus in sleep

Children with ESES show elevated CSF IL-1β, TNF-α, IL-1α, and caspase-1 compared with non-ESES controls. IL-1β correlates with caspase-1 and TNF-α. Supports inflammasome involvement and biological rationale for anti-inflammatory therapy.

Indexed context

(2025 authors)

dee-swasesescswscsf-cytokinesneuroinflammation

Markdown path

content/research/papers/2025-eses-csf-cytokines-il1b-tnf.md

Findings

Children with ESES show elevated CSF IL-1β, TNF-α, IL-1α, and caspase-1 compared with non-ESES controls. IL-1β correlates with caspase-1 and TNF-α. Supports inflammasome involvement and biological rationale for anti-inflammatory therapy.

Why it may matter for Levi

Single strongest justification for obtaining repeat CSF cytokines in Levi. The April 7, 2026 LP did not send cytokines, which is the biggest avoidable diagnostic gap in his current workup.

Paper text

Increased expression of proinflammatory cytokines in the cerebrospinal fluid of patients with a history of electrical status epilepticus in sleep

(2025 authors) — peer-reviewed journal (PubMed 40323354) (2025). https://pubmed.ncbi.nlm.nih.gov/40323354/

Findings summary

Children with ESES show elevated CSF IL-1β, TNF-α, IL-1α, and caspase-1 compared with non-ESES controls. IL-1β correlates with caspase-1 and TNF-α. Supports inflammasome involvement and biological rationale for anti-inflammatory therapy.

Relevance to Levi

Single strongest justification for obtaining repeat CSF cytokines in Levi. The April 7, 2026 LP did not send cytokines, which is the biggest avoidable diagnostic gap in his current workup.

Provenance

  • Ingested 2026-04-16 as part of the batch literature pass supporting the Root Cause Theories, diagnostics, and treatments workspaces.
  • No PDF ingested into storage/; canonical link is the URL above.
  • Companion memo: content/research/notes/2026-04-16-literature-pass.md